Acetaminophen is metabolized by sulfation and glucuronide conjugation.E - Conjugated and unconjugated excreted through kidneys.5-10% - Metabolism through CYP450/CYP2E1 (Forms NAPQI).Antipyresis through inhibition of hypothalamic heat center.Possibly through inhibition of Cyclooxygenase-3 (COX-3).Initial loading dose of NAC is 150 mg/kg IV (140 mg/kg PO).Give NAC if level is >150 mcg/mL four hours post-ingestion.200 mg/kg in healthy children 1-6 years of age.>6 g or >150 mg/kg per 24hr period x 2days.>10 g or >200 mg/kg as single ingestion or over 24hr period OR.Now the most common cause of acute liver failure in the US.Includes Tylenol and numerous brands and products including acetaminophen.2.4 Stage 4 (after day 5, up to 2 weeks).
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